Healthy bee colonies build brood faster in the spring, and will winter extremely well when their intestinal integrity is intact. Exceptional colonies can be built using all natural Nozevit as a food supplement for intestinal cleansing. Just mix Nozevit in with your sugar syrup in Spring or Autumn. For Preventive Care: Use 2 Applications, 10 days apart. For Critical Care: Use 4 Applications, 4 days apart. 15ml straws: enough for 15 single Applications 20ml Bottle enough for 20 single Applications: 50ml Bottle: enough for 50 single Applications. 4 year shelf life.